Like mother, like daughter, like granddaughter… Transgenerational ignorance engendered by a defective reproductive health technology.

Emmanuelle Fillion,Didier Torny

doi:10.1016/j.rbms.2021.10.001

Abstract

From 1941, the synthetic oestrogen diethylstilbestrol (DES) was administered to millions of women around the world to prevent miscarriages. In 1971, a clear and direct link was shown between taking DES during pregnancy and its subsequent long-term morbid effects on offspring. In the last 50 years, the list of side effects of in-utero exposure to DES has grown to include cancer, infertility, significant prematurity and urogenital malformation, amongst others. Based on qualitative sociological research conducted between 2010 and 2013, compiling archives, judicial documents and 108 interviews, this article illustrates a continuous production of ignorance in France. By focusing on DES as a reproductive health technology, three aspects are stressed. First, in terms of recognition of adverse effects, despite DES being identified as a prototype for other technologies such as the contraceptive pill or hormone replacement therapy, there remained a strong reluctance to import knowledge from the USA on its dangers and risks. Second, there was indifference to transgenerational side effects: even when the most visible effects of DES were finally acknowledged, there was a lack of consideration of the health of descendants; an inability to deem the knowledge of these repercussions as emancipatory or potentially empowering for the offspring. Third, regarding the health care of DES daughters, an important propensity to undone science is highlighted, with notable indifference to the risks of hormonalization of the female body, even on the part of activists. Thus, decades after it was last given to pregnant women, the shadow of DES still lingers as a failed reproductive health technology.

Highlights

Introduction Diethylstilbestrol (DES), a synthetic oestrogen, has long been regarded as a ‘magic pill’, and in particular as a simple way to bring pregnancies to term, resulting in happy parents of a ‘healthy baby’
Exhaustive documentary research was performed, ranging from scientific literature to documents pertaining to the production of civil organizations, and even individual testimonies and blogs
In June 1983, a group of researchers commissioned by the French Institute of Health and Medical Research conducted a study and found that 200,000 women had been treated with DES in France, and 160,000 living babies had been exposed in utero

Summary

Introduction

Introduction Diethylstilbestrol (DES), a synthetic oestrogen, has long been regarded as a ‘magic pill’, and in particular as a simple way to bring pregnancies to term, resulting in happy parents of a ‘healthy baby’. No more use of past knowledge: indifference to the transgenerational question At the time of the public discussion of DES in the national press, in March 1983, the National Pharmacovigilance Commission did not mention the increased risk of late abortions or ectopic pregnancies, these were already documented in the US literature.

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Conclusion