LIGNANS FROM SHIZANDRA CHINENSIS SEMINA OLEUM EXTRACT

Abstract

was realized in “cruciform raised labyrinth” (CRl). The labyrinth installation was central square area (10c10 cm) with four “corridors” (boards with width of 10 cm and length of 50 cm) that moved off from every wall. Two of them oppositely placed “closed corridors” were limited on sides to walls that height of which was 40 cm, two ones were “opened corridors” that were without any walls. The installation was raised at a height of 50 cm above floor level and was illuminated from one side by a lamp with power of 50 W. A rat was placed on a central area so that their muzzles were against opened corridor. After that number of visits in closed and opened corridors and general time, that a rat was there, were registered. Every animal was been supervised for 5 minutes. On the 8 th day of the experiment method of conditioned reaction of passive avoidance was used: animals were tough in the installation that had light and dark compartments with electrode floor. The compartments were divided by partition with hole of a wire 4 cm. in diameter stretch. Animal was placed in light compartment and after its movement in dark compartment; electric painful irritation was provoked by series of switching on current in electrode floor with power of 1,5 mA during 1 sec in 2 sec. Thereby reflex of “dark compartment” was formed. Nootropic activity of test drug was estimated according to duration of latent period (safety of memorial track) up to animal’s movement from light to dark compartment of installation in 1,3 and 7 twenty-four hours after teaching. in test