Abstract
was realized in “cruciform raised labyrinth” (CRl). The labyrinth installation was central square area (10c10 cm) with four “corridors” (boards with width of 10 cm and length of 50 cm) that moved off from every wall. Two of them oppositely placed “closed corridors” were limited on sides to walls that height of which was 40 cm, two ones were “opened corridors” that were without any walls. The installation was raised at a height of 50 cm above floor level and was illuminated from one side by a lamp with power of 50 W. A rat was placed on a central area so that their muzzles were against opened corridor. After that number of visits in closed and opened corridors and general time, that a rat was there, were registered. Every animal was been supervised for 5 minutes. On the 8 th day of the experiment method of conditioned reaction of passive avoidance was used: animals were tough in the installation that had light and dark compartments with electrode floor. The compartments were divided by partition with hole of a wire 4 cm. in diameter stretch. Animal was placed in light compartment and after its movement in dark compartment; electric painful irritation was provoked by series of switching on current in electrode floor with power of 1,5 mA during 1 sec in 2 sec. Thereby reflex of “dark compartment” was formed. Nootropic activity of test drug was estimated according to duration of latent period (safety of memorial track) up to animal’s movement from light to dark compartment of installation in 1,3 and 7 twenty-four hours after teaching. in test
Highlights
Shisandra shinensis semina was obtained by original technology (1) with various fatty oils
Diabetes mellitus is characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and protein and an increased risk of complication of vascular diseases
Type 2 diabetes mellitus is characterized by derangement of insulin secretion and an inability of the peripheral tissues to respond to insulin
Summary
Biological activity of Shizandra fruits and semina is caused by special group of chemical compounds — lignans (shizandrins, fig.). They are lypophylic components and can be extracted by non-polar extragents. Shisandra shinensis semina was obtained by original technology (1) with various fatty oils. The aim of the present work was to study lignans composition and content in Shisandra shinensis semina oil extracts. Content of the dominant lignans was (in %wt): shizandrol A 0,088–0,102, shizandrol B 0,075–0,087, shi-. Relations between individual lignans were about 1:1:0,2:0,2:1. This is optimal for adaptogenic properties of Shizandra drugs (2). Fatty oils are effective for shizandra lignans extraction.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
