Abstract
Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.
Highlights
Lignans are a large group of naturally occurring compounds that are derived from the shikimic acid biosynthetic pathway [1]
Integrase inhibition, and topoisomerase inhibition are included as the reported to this review, many lignans have been identified with antiviral activities [11].mechanisms
Was initially founded in the resin of the creosote bush of different subtypes of classical lignans, the main structural feature of this subclass is the β-β structure of different subtypes of classical lignans, the main structural feature of this subclass is the the nordihydroguaiaretic acid (NDGA), it was tested the antiviral effects against West Nile Virus (WNV) and Zika Virus (ZIKV) simultaneously with NDGA; Dibenzylbutane is the basic structure of classical lignan, other subtypes of lignans β-β′
Summary
Lignans are a large group of naturally occurring compounds that are derived from the shikimic acid biosynthetic pathway [1]. Lignans are found in over 70 families in plant kingdom, and more than 200 classical lignans and 100 neolignans have been characterized [6]. They are usually present as dimers, but some of them are trimers or tetramers. Antibacterial immunosuppressive [9],antiviral and antiasthmatic properties [10]reverse were transcriptase reported. Integrase inhibition, and topoisomerase inhibition are included as the reported to this review, many lignans have been identified with antiviral activities [11].mechanisms.
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