Light/Ultrasound Responsive 750 nm‐Emitted Non‐toxic Indium Phosphide Quantum Dots Hybrid Nanobubble for Brain Tumor Imaging

Abstract

BackgroundThe blood‐brain barrier (BBB) hardly allows all substances to pass. Except for oxygen, carbon dioxide, and blood sugar, most dyes and proteins are generally unable to pass due to their molecular structure. Therefore, bioimaging in brain tumor is very challenging. Moreover, different diagnostic methods have their own advantages and disadvantages. Composite imaging is considered to be a more efficient method of bioimaging.DesignThe study initially constructed an ultrasonic imaging material that can be used for quantum dot bonding, which allows the nanomaterial to have both supersonic and optical diagnosis. We intend to synthesize lipid‐phase nanobubbles to combine with 750 nm emitted non‐toxic indium phosphide (InP) quantum dots, providing multiple imaging functions. Choose for high biocompatibility and for in vivo and in situ diagnosis. Moreover, recent researches have demonstrated that cavitated nanobubbles can introduce a small opening in the BBB, allowing materials extravasation. It makes InP Quantum dots can enter in brain tissue to generate the near‐infrared signal for the signal tracking.ResultsNanobubble subjected to a shock wave that disrupts the BBB. The cavitation effect makes an opening space, allowing small particles extravasation. InP quantum dots‐loaded nanobubbles activated by ultrasound can temporarily permeabilize into the BBB, causing quantum dots accumulation in the brain tumor tissue, as evidenced by ultrasound and fluorescence imaging.ConclusionsNanobubbles cavitation bioimaging displays the mean intensity of acoustic cavitation over time and was correlated with areas of acoustic cavitation‐induced BBB opening. After combining the InP quantum dots to the lipid bubbles, the nanocomposite is expected to have the functions of ultrasonic and optical imaging. We chose the best near‐infrared light to make the signal of brain tumor can be detected.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.