Abstract
Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic agent with rapid hemostasis and excellent antibacterial activity. In this study, we developed a light responsive hemostatic film for effective handling of liver bleeding with promising photodynamic therapy against S. aureus onnear infrared (NIR) irradiation. Based on silk fibroin, the film exhibited desirable biocompatibility and mechanical property as a hemostat tape. Significantly, the film tape achieved excellent tissue adhesion and hemostasis in vivo within 2 min of UV exposure, which would have a great potential as a multifunctional biomedical material in the field of tissue repair such as wound healing, bone repair, and nerve regeneration.
Highlights
Massive hemorrhage caused by trauma, traffic accidents, and surgery can lead to excessive blood loss and even death if the effective control of bleeding is not in time (Han et al, 2020; Qiao et al, 2021; Roy et al, 2021)
We developed a silk fibroin based antibacterial film as a rapid hemostatic agent for treating hemorrhage in deep wounds
The MASiF and C-MASif films were successfully fabricated and Figure 2A displays that both films were transparent and C-MASif film possessed dark color, due to Ce6 moiety on silk fibroin chains
Summary
Massive hemorrhage caused by trauma, traffic accidents, and surgery can lead to excessive blood loss and even death if the effective control of bleeding is not in time (Han et al, 2020; Qiao et al, 2021; Roy et al, 2021). Commercial hemostats, such as gauze, gelatin sponge, and bandages, have been considered to be highly effective in handling bleeding by sealing the wound surface of the bleeding site (Arnaud et al, 2008; Lan et al, 2015; Vilardo et al, 2017). For hemostasis, it has been reported that SF can bind with fibrinogen and blood platelets to facilitate the clotting cascade
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