Abstract
AbstractCell migration is an essential physiological process in the life cycle of cells, playing a crucial role in cancer metastasis, neural development, and cellular immune response. However, achieving precise control of cell migration at single‐cell level is challenging due to the intricate and diverse microenvironments of cells. Here, an optical technique is presented that utilizes light‐actuated micronavigators to guide the directional migration of individual cells both in vitro and in vivo. Employing high‐speed scanning optical tweezers, micronavigators near target cells are trapped and rotated at a rotation speed of up to 12 000 rpm, which, to the best of knowledge, represents the fastest rotation of light‐driven micromotors in a biological environment to date. The micronavigators generate a powerful fluid shear force (up to 40 pN) which can guide the migration of immune and nerve cells in a predetermined direction. Furthermore, micronavigators are employed to guide cell migration in various biological systems, including lab‐on‐a‐chip devices and blood vessels within living animals. This technique offers new opportunities for controlling cell migration, enabling precise immune activation, and neuron repair at the single‐cell level.
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