Abstract

Eosinophilic esophagitis (EoE) is an eosinophil predominant, chronic allergic disease with increasing prevalence. Tissue remodeling is a hallmark complication in EoE and associates with clinical dysphagia and strictures. We recently defined a putative role for TNFSF14/LIGHT in promoting an inflammatory esophageal fibroblast phenotype. However, the effects of LIGHT deficiency on EoE pathogenesis in vivo remain unknown. Here we investigated the impact of LIGHT deficiency in a murine model of chronic EoE.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.