Abstract
This work describes the development of a photoelectrochemical sensor for glucose quantification exploiting a light assisted-batch injection analysis (BIA) cell. A light-emitting diode (LED) lamp was employed to control the incidence of light on the p-Cu2O/n-Cu2O/fluorine-doped tin oxide (FTO) photoactive platform in BIA cell. The p-Cu2O/n-Cu2O/FTO platform was constructed by electrodepositing n-Cu2O and p-Cu2O and the characteristics of electrodeposited Cu2O films were investigated by X-ray diffraction (XRD), Raman spectroscopy, and electrochemical impedance spectroscopy. The light assisted-batch injection analysis of glucose based on the illuminated p-Cu2O/n-Cu2O/FTO photoelectrode presented a linear response of 10 μmol L-1-1 mmol L-1, a limit of detection of 4.0 μmol L-1, and sensitivity of 0.768 ± 0.011 μA L μmol-1 cm-2. The system presented an average recovery value of 96% when applied to the determination of glucose in an artificial saliva sample, which indicates that the incidence of light on photoelectroactive platforms is a promising approach for the determination and quantification of glucose.
Highlights
Glucose is an essential monosaccharide for the proper functioning of living organisms.[1]
Enzymatic glucose sensors are mainly based on the immobilization of the enzyme glucose oxidase (GOx) on various substrates and currently they play an important role in the detection of blood glucose due to its high selectivity and sensitivity.[11,12]
Nonenzymatic sensors for glucose do not require the use of enzymes which contribute to the stability, simplicity and reproducibility of the platforms developed for glucose detection.[13]
Summary
Glucose is an essential monosaccharide for the proper functioning of living organisms.[1]. Enzymatic glucose sensors are mainly based on the immobilization of the enzyme glucose oxidase (GOx) on various substrates and currently they play an important role in the detection of blood glucose due to its high selectivity and sensitivity.[11,12] On the other hand, non-enzymatic sensors for glucose are based on the direct electro-oxidation of glucose on the surface of a catalyst. Nonenzymatic sensors for glucose do not require the use of enzymes which contribute to the stability, simplicity and reproducibility of the platforms developed for glucose detection.[13] Among the several classes of sensors recently proposed for glucose determination, the electrochemical methods appear as an inexpensive, fast, accurate, sensitive, and portable, being a low-cost and straightforward alternative to measure glucose levels in different types of samples.[14]
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