Abstract
The morphology of an autonomous diethylstilbestrol-induced pituitary tumor (Furth’s tumor MtT-F4) has been studied by light and electron microscopy. This tumor, besides having mammotrophic and somatotrophic activities, exerts an adrenocorticotrophic effect. The cells of the tumors contain minute, faintly stainable granules. In electron micrographs, there is but one type of secretory granule, measuring up to about 350 ran m diameter. It has the same appearance as the acidophil granules of the so-called growth hormone type. The findings are discussed with respect to the possibility that the pituitary gland contains pluripotent cells whose secretion can be differentiated to satisfy functional demands and that this causes them to present morphological characteristics of either basophils or acidophils. (Endocrinology 75: 893, 1964)
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