Abstract
Two morphologically different cell types are involved in the production of immunological sensitization against many antigens, namely, macrophages and lymphocytes (e.g., 4, 15, 22, 3). Applying antisera specifically directed against either of these cells may result in a delay or suppression of the primary immunological response. This has been proved to be true for antithymocyte sera (ATS) (e.g., 23, 8, 14, 1). Also, studies on the in vivo action of antimacrophage sera (AMS) revealed prolongation of allogeneic skin graft survival time in rats (17). The present work intends to elucidate morphologically whether or not the apparently similar effect of these antisera (prolongation of skin graft survival time) is caused by a specific action on different target cells (lymphocytes and macrophages) in vivo. Therefore, we studied the morphological alterations in popliteal lymph nodes following local application of either antiserum. The electron microscopic observations presented here are added to recently published light microscopic and enzyme histochemical studies (19, 20).
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