Abstract
New cobaltous complexes of a hydrazone ligand (HQinAx) containing quinoline and alloxan nuclei were synthesized. The composition and structure of the produced Co(II)-HQinAx complexes were successfully determined using spectroscopic and analytical techniques. Molar conductivity tests showed the neutral characters of Co-HQinAx complexes. The results illustrated that HQinAx behaves as a neutral/mono-, bi- and tri-anionic bi-, tri- and penta-dentate chelating agent. The obtained complexes have octahedral and square-planar geometries. Thermodynamic parameters were effectively calculated after investigating the thermal decomposition patterns of Co-HQinAx complexes in relation to structure. Density functional theory (DFT) level at B3LYP/6-311G(d,p) and LanL2dz level was used to evaluate the molecular structural features of HQinAx and its Co(II) complexes. Co-HQinAx complexes showed an anticancer action against Ehrlich Ascites Carcinoma. A molecular docking investigation was performed to verify the recorded biological activity of the new compounds by determining how they interact with EFP inhibitor with CDK-2 (PDB ID: 3IG7).
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