Abstract
Researchers in recent years are working on different approaches to the problem of bacteria resistant to antibiotics through drug modification. The synthesis of metal drug complexes are becoming more popular than their parent drugs because they possess modified pharmacological, toxicological and physiochemical properties. In this study, amoxicillin complexes of copper and zinc (II) ions were synthesized using standard method. The complexes were characterized for aqueous solubility, UV-visible spectral, acid stability, and thermal stability and in-vitro antimicrobial activities. The results of the physiochemical properties showed evidence of complex formation between the metals and the ligand. The acid and thermal stability of amoxicillin complexes showed high acid and thermal stability than its parent form. In-vitro antimicrobial activity of amoxicillin and its complexes form were studied against Staphylococcus aureus and Pseudomonas aeruginosa. The results revealed that Amoxicillin complexes of copper (II) ions showed effective antibacterial effect on Staphylococcus aureus than its pure form while Amoxicillin Zn2+ showed lower antibacterial activity when compared to its parent drug. This study suggests that transition metal complexes of amoxicillin modify the properties of the parent drug.
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