Abstract
Ligands and Receptors of the Interleukin-1 Family in Immunity and Disease
Highlights
The discovery of the importance of IL-1 in defense against bacteria and of the Toll-IL-1 resistance (TIR, as originally defined) domain was upstream of the discovery of Toll-like receptors [2]
In particular they focus on the new IL1 family members, IL-37 and the cytokines belonging to the IL-36 subfamily and on the potency of blocking IL-1 in disease
Members of IL-1R like receptor family include signaling molecules and negative regulators. We present the latter, which include the prototypic decoy receptor type 2 IL-1R and “receptors” with regulatory function, such as TIR8/SIGIRR [11]
Summary
The discovery of the importance of IL-1 in defense against bacteria and of the Toll-IL-1 resistance (TIR, as originally defined) domain was upstream of the discovery of Toll-like receptors [2]. This volume brings together eight articles that are intended to provide a summary about IL-1 family ligand and receptors in inflammation and immunity. Van de Veerdonk et al focus their review on the IL-1 family of ligands, describe their biological functions and provide new insights in their biology [8].
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