Abstract
Publisher Summary This chapter discusses the ligand-induced conformational changes in ribonucleic acids (RNAs). This chapter also discusses the newer results on induced structural changes in transfer ribonucleic acids (tRNA), focusing on codon-induced changes, and then emphasize a new aspect— namely, the evidence for allosteric conformational changes in nucleic acids. Transfer RNAs are recognized by two different classes of proteins: those that bind only to their cognate tRNAs (like aminoacyl synthetases) and the elongation factor EF-Tu, that form complexes with all aminoacylated tRNAs. Transfer RNA (tRNA) may exist as both aminoacyl- or peptidyl-tRNA and several isoacceptor tRNAs may exist for only one amino acid. Besides a complicated tertiary structure and many modified nucleosides, there is a third way to ease the correlation of structure, with the many tRNA functions. Like proteins, tRNA may undergo induced structural transitions and there may be one defined tRNA conformation for every biochemical process. The chapter also discusses induced allosteric conformational changes in tRNA.
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