Ligand‐free Palladium‐Catalyzed Carbonylative Suzuki Coupling of Aryl Iodides in Aqueous CH3CN with Sub‐stoichiometric Amount of Mo(CO)6 as CO Source

Abstract

AbstractA new method for the synthesis of diaryl and heterodiaryl ketones has been established based on the palladium‐catalyzed carbonylative Suzuki coupling approach with sub‐stoichiometric Mo(CO)6 as CO source. Using 0.5 mol% of Pd(TFA)2 as catalyst, 0.5 equivalent of Mo(CO)6 as solid carbonyl reagent and 3 equivalent of K3PO4 as base, a wide range of functionalized (hetero)aryl iodides and (hetero)aryl boronic acids could smoothly proceed the carbonylative cross‐coupling reaction in aqueous CH3CN at 50 °C, affording the corresponding ketones in good to excellent yields. The newly developed method was easy to operate under mild conditions with high efficiency.magnified image