Abstract
The senescence accelerated mouse (SAM) is known as a murine model of aging and memory dysfunction. In the cerebral cortical membranes of male 9-month-old SAM mice, the B max values of [ 3H]rauwolscine and [ 3H]nitrendipine binding, and the values of both K d and B max of [ 3H]TCP binding in the accelerated aging strain SAM-P 8 were significantly increased compared with the values in the control strain SAM-R 1 . In hippocampal membranes, however, the B max values of [ 3H]quinuclidinyl benzilate and [ 3H]nitrendipine binding were significantly decreased in SAM-P 8 compared with those in SAM-R 1 . These results suggest that muscarinic acetylcholine receptors, α 2-adrenoceptors, N- methyl- d-aspartate receptor channels and L-type Ca 2+ channels are changed in cerebral cortex and hippocampus in SAM-P 8 at 9 months.
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