Abstract
Aims: The current research has shown that the complications of hypertensive diabetes have a great impact on the body. Telmisartan, an angiotensin II antagonist, has the dual role of antihypertensive and antidiabetics effects. This research aims to find a novel compound to treat hypertensive diabetes. Study Design: Taking telmisartan as the lead compound to explore the active compounds with a similar structure is the orientation to explore new hypertensive diabetes drugs. The target compounds enhance the partial activity of PPARγ with the retention of antagonistic activity of AT1R. Place and Duration of Study: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, between November 2017 and April 2018. Methodology: In this paper, high-throughput screening the virtual compounds library, by docking, ADMET prediction and molecular dynamics of PPARγ/AT1 dual target active drugs, the target compound has similar chemical characteristics of the original ligand. Results: The representative compound 544 has better pharmacokinetic properties and shows a good combination with both targets. The complexes of the compound with both targets were simulated for 20ns, respectively, and the binding mode was stable. Conclusion: This work aims to find the novel PPARγ/AT1 dually active compounds in the treatment of hypertensive diabetes complication. The study can effectively reduce the impact of drug metabolism on the liver and kidney, adverse reactions and some other side effects.
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