LIFU for major depressive disorder - Targeting the neural networks of depression

Abstract

LIFU for major depressive disorder - Targeting the neural networks of depression Tiago Costa, Assistant Professor at the Department of Microelectronics, Delft University of Technology, discusses opportunities surrounding low-intensity focused ultrasound in the treatment of major depressive disorder in a minimally invasive manner. Major depressive disorder (MDD) is a prevalent and debilitating mental health condition affecting millions worldwide. While various treatment options exist, including medication and psychotherapy, a significant proportion of individuals with MDD do not achieve full remission or experience adverse side effects from existing treatments. Consequently, there is a need for innovative and effective therapeutic approaches to address this complex disorder. One emerging and promising area of research is the use of low-intensity focused ultrasound (LIFU) to treat major depressive disorder. LIFU is a non-invasive technique that utilises ultrasound waves at lower intensities compared to high-intensity focused ultrasound (HIFU), which is used for the thermal ablation of tissue. By focusing these ultrasound waves on specific brain regions, LIFU has shown potential in modulating neural activity and potentially alleviating depressive symptoms.