Abstract
Lifting the veil on fungal toxins.
Highlights
The outcome of a pathogenic microbial infection is dictated by host − pathogen interactions and requires constant rapid adaptive responses by both the microbe and the host
Candida albicans is a fungal commensal of human skin and mucosal surfaces that can transition into an invasive fungal pathogen within immunocompromised individuals
In a paper recently published in Nature, Moyes et al.[10] screened a library of C. albicans gene deletion mutants for their ability to cause damage to oral epithelial cells and to trigger host immune signaling pathways
Summary
The outcome of a pathogenic microbial infection is dictated by host − pathogen interactions and requires constant rapid adaptive responses by both the microbe and the host. While pathogenic bacteria and viruses promote infection via the ‘proactive’ secretion of toxins and virulence proteins to hijack host machinery, the dogma of fungal pathogenesis to date has been one of almost ‘accidental’ evolutionary, adaptive survival.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have