Abstract
Einleitung Colorectal cancer (CRC) is an ongoing medical challenge and the third most common cause of death for both sexes worldwide. The tumour microenvironment is considered a critical component playing a major role during the development, including metastasis in CRC. Cancer-associated fibroblasts (CAFs) within the tumour stroma exert various functions, such as direct interactions with cancer cells and secretion of soluble growth factors [1] [2] [3]. Recent data suggest a contribution of the Leukemia inhibitory factor (LIF) and its signaling in CAFs during disease progression in CRC. However, the specific role of CAF-associated LIF receptor (LIFR) signaling in CRC is not fully understood.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
