Lifitegrast, Bezlotoxumab, and Sugammadex sodium

Abstract

Dry eye disease is estimated to affect 16 million American adults and is typically associated with reduced production of tears and altered composition of tears. The incidence increases with age and 10% to 15% of adults over the age of 65 years experience this disorder. It occurs more commonly in women, and causative or contributing factors include environmental conditions, diseases such as Sjögren syndrome, and the use of medications such as those with anticholinergic activity. Inflammation of the ocular surface occurs, and in addition to eye dryness, symptoms may include eye stinging, burning, or other discomfort, a gritty feeling, and blurred vision. Common activities such as reading, working at a computer, watching television, and use of contact lenses may be interrupted, and the eyes may be more sensitive to bright light and other environmental factors (e.g., windy conditions, air inside an airplane). Dry eye is usually a chronic disease, and if it becomes severe and is left untreated, pain, corneal ulceration, and scars may result. Daniel A. Hussar, PhD, Remington Professor of Pharmacy, University of the Sciences, Philadelphia, PA Robert Scott Cheeseman, II, Student Pharmacist, Philadelphia College of Pharmacy, Philadelphia, PA