Abstract
Current evidence supports the hypothesis that the cortical Aβ burden may be higher in MCI patients with a lifetime history of depression (LMD) in comparison to MCI patients without an LMD. However, to date, no previous PET study has directly tested this hypothesis. Therefore, we compared the AV-45 standardized uptake value ratios (SUVR) between amnestic MCI patients with an LMD (aMCI+LMD) and amnestic MCI patients without an LMD (aMCI-LMD) in order to examine whether aMCI patients with an LMD show a higher Aβ deposition than those without an LMD, using data from Alzheimer's Disease Neuroimaging Initiative (ADNI) databases.
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