Abstract
Treatment–resistant depression (TRD) is defined as failing to fully remit after 2 antidepressant treatments of adequate dose and duration. A study that analyzed commercial insurance claims, Medicaid, and the Veterans Administration populations showed TRD to be a very costly healthcare disorder thereby making TRD a major public health concern for policymakers. Studies were analyzed and the results of the cost–effective lifestyle medicine practices in treating TRD are shared. Recommendations include further funding and resources and more advanced research in using lifestyle medicine to treat TRD and other mental health problems.
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