Lifestyle Factors Do Not Meaningfully Impact Age-Based AMH Levels in Non-Infertile Women [30O

Abstract

INTRODUCTION: Increasing age has a well-established negative association on ovarian reserve, reflected in decreasing AMH levels. The role of lifestyle on physiologic AMH levels is unknown. The aim of the study was to identify whether lifestyle factors impact AMH levels in a cohort of non-infertile women. METHODS: This retrospective cohort study includes all initial oocyte cryopreservation consultations from 3/1/2016 to 9/30/2018 at Extend Fertility Medical Practice. The study was granted IRB exempt status. Subjects were asked about smoking, drug use, caffeine intake, and exercise frequency. AMH levels were measured at an independent laboratory on the Gen-II ELISA platform. Lifestyle and BMI data were categorized. AMH levels were log transformed to approximate normal distribution. Linear regression analyses were performed controlling for age. RESULTS: 2623 subjects were included in the study. Mean age 35.9±3.5 years. Median AMH 1.93 ng/mL [IQR 0.99-3.52]. Smoking, drug use, or caffeine intake were not significantly associated with age-controlled AMH levels. There was a trend towards an association with lower AMH levels for underweight (BMI<18.5kg/m2) and obese (BMI>30kg/m2) subjects (P=.03, P=.05 when controlled for age). Exercising more than two times per week was weakly associated with higher AMH levels (P=.03). CONCLUSION: This data supports that physiologic AMH levels are not meaningfully impacted by lifestyle factors such as exposure to caffeine, smoking, or drug use. The incidence of current smokers in our population was small and therefore the impact may be underestimated. A healthy body weight and exercise regimen may be associated with higher AMH levels, even when controlling for age.