Abstract
IntroductionIn the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors (weight, smoking amount, cumulative duration of different sports activities) and lumbar disc disease.MethodsIn four German study regions (Frankfurt am Main, Freiburg, Halle/Saale, Regensburg), 564 male and female patients with lumbar disc herniation and 351 patients with lumbar disc narrowing (chondrosis) aged 25 to 70 years were prospectively recruited. From the regional population registers, 901 population control subjects were randomly selected. In a structured personal interview, we enquired as to body weight at different ages, body height, cumulative smoking amount and cumulative duration of different sports activities. Confounders were selected according to biological plausibility and to the change-in-estimate criterion. Adjusted, gender-stratified odds ratios with 95% confidence intervals were calculated using unconditional logistic regression analysis.ResultsThe results of this case-control study reveal a positive association between weight and lumbar disc herniation as well as lumbar disc narrowing among men and women. A medium amount of pack-years was associated with lumbar disc herniation and narrowing in men and women. A non-significantly lowered risk of lumbar disc disease was found in men with high levels of cumulative body building and strength training.ConclusionsAccording to our multi-center case-control study, body weight might be related to lumbar disc herniation as well as to lumbar disc narrowing. Further research should clarify the potential protective role of body building or strength training on lumbar disc disease.
Highlights
IntroductionIn the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors (weight, smoking amount, cumulative duration of different sports activities) and lumbar disc disease
In the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors and lumbar disc disease
Association between lumbar disc disease and body mass index odds ratio (OR) for risk of lumbar disc disease are presented in Table 2 for men and in Table 3 for women
Summary
In the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors (weight, smoking amount, cumulative duration of different sports activities) and lumbar disc disease. Disc-related diseases of the lumbar spine, such as lumbar disc herniation and disc narrowing, are common health problems and frequently lead to work disability. Cardiovascular risk factors and unhealthy lifestyle-related factors (for example, excess weight, smoking, and physical inactivity) potentially constitute risk factors for lumbar disc disease; non-occupational risk factors were assessed in detail. The aim of the present analysis was to assess the doseresponse relationship between lifestyle-related factors (smoking, body mass index [BMI], and sports activities) and lumbar disc disease (lumbar disc herniation and lumbar disc narrowing) on the basis of data of the EPILIFT Study
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