Abstract
The effect of a high fat diet on life span depends on strain and sex of the animal tested and is specifically due to the fat content, and not to the high caloric value, of the diet. In male mice of strain C57BL, feeding of a high fat diet from the ages of 1, 6, or 12 months on through life shortened the life span. If the high fat diet was given for a limited period of time, the effect on life span depended on the age at which these mice were placed on the high fat ration.
Published Version
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