Abstract

Intraperitoneal administration of OK-432 prolonged life span of CDF1 mice bearing P388. Cell-mediated immune response of the host was investigated in vitro with the method of electrophoretic mobility of macrophage. At the early stage of tumor development, the cell-mediated immune response of the host treated with OK-432 was kept stronger than that of the untreated one. However, at the advanced stage of tumor development, there was little difference in the cell mediated immune response between both groups. The host was found to be more immunosuppressed than that at the early stage of tumor development.

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