Abstract
Life of mice - development of cardiac energetics
Highlights
The operational mechanism, structure and development of the barriers responsible for energetic compartmentation within cardiomyocytes have yet to be elucidated despite intensive research in this area
sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function was measured via calcium mediated tension generation, while myosin ATPase function was quantified by measuring rigor tension development
Throughput of energy transfer between mitochondria and myosin ATPases is correlated with the changes in the cytoarchitecture in contrast to the creatine kinase (CK) supported energy transfer which seems to depend on specific localization and expression of CK
Summary
The operational mechanism, structure and development of the barriers responsible for energetic compartmentation within cardiomyocytes have yet to be elucidated despite intensive research in this area. A recent article in The Journal of Physiology by Piquereau et al (2010) is an extensive investigation into how the structural and energetic properties of mouse heart muscle change during postnatal development. It includes observations on structural changes and cellular morphology using electron microscopy, quantification of mitochondrial, myofibrillar and SR proteins, assessment of organelle functionality, and the quantification of the energy flux in both the CK and DANC transfer systems.
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