Abstract
“Biology is Technology”, this title of a book authored by bioengineer Rob Carlson captures the essence of synthetic biology. This novel research field is in the hands of engineers, who are in charge of redesigning life or designing new forms of life for specific purposes. In the aftermath of “the century of the gene” (Evelyn Fox Keller, Cambridge Mass, Harvard University Press, 2002) he comes the century of “life by design”. As the emergence of molecular biology allowed reading the code of life, it seems quite natural to rewrite it with the alphabet. “From reading to writing the genetic code”, this is how Craig Venter, a genetic engineer who designed the first bacteria with a synthetic genome in 2010, explains and legitimizes his research programme. It seems to be a logical inference based on a chronological sequence.The prospect of designing organisms triggers the promise of manufacture of all sorts of organisms to meet societal demands or human desires and fantasies: From bacteria-workers to the creation of new forms of life or even…immortal life. Just as in nanotechnology, synthetic biology develops an “economy of promises”. However synthetic biology seems to go one step further. While nanotechnology has been advertised with the slogan “shaping the world atom by atom” in the 2000 US National NanoInitiative, synthetic biology opens up the more challenging perspective of designing organisms that will remake the world for us . Re-engineered yeasts or bacteria will serve as pharmaceutical plants producing drugs. Synthetic algae will provide renewable fuel for our daily consumption of energy. Synthetic bacteria will decontaminate the soils polluted by chemicals and nuclear waste.This paper outlines a number of distinctive features of this emerging field in the constellation of bionanotechnologies. It then insists on the variety of research agendas and strategies gathered under the umbrella “synthetic biology”. While redesigning life is the central goal, synthetic biologists do not develop a uniform view of living organisms.
Highlights
This novel research field is in the hands of engineers, who are in charge of redesigning life or designing new forms of life for specific purposes
As the emergence of molecular biology allowed reading the code of life, it seems quite natural to rewrite it with the alphabet
“From reading to writing the genetic code”, this is how Craig Venter, a genetic engineer who designed the first bacteria with a synthetic genome in 2010, explains and legitimizes his research programme
Summary
The iGEM competition subverts the hierarchical organization of laboratory life with seniors and doctors supervising juniors and undergraduates It appeals to the creativity of young people by encouraging their self-organization and autonomy and applying non-standard criteria of evaluation of research projects. They are actively promoting garage biology with the view to develop a critical mass of data for synthetic biology to take off They promote new property regimes aimed at establishing various forms of “open biology” inspired by the open source movement in information technology. There is a variety of research agendas gathered under the umbrella “synthetic biology” Biobricks, synthetic DNA, xeno-DNA, minimal genomes, and protocells could arguably be presented as exemplars of the current movement of Converging Technologies prompted by the nanotechnology wave They belong to a special branch of biology often coupled with systems biology. The sister science, aims at understanding collective behaviour of biological interactions through computing and modelling, while synthetic biology is about synthesizing biological entities
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