Abstract
The synthetic approach for the C20–C29 and C20–C34 fragments of amphidinolide F and C was based on an original Liebeskind–Srogl cross-coupling reaction with a glutamic acid-derived building-block. Further highly diastereoselective reduction of the ketone was achieved by using an uncommon Ph3SiH/TBAF/HMPA system. The amphidinolide C side chain was built through a reductive elimination of chiral epoxide to install the stereogenic center at C29.
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