Abstract
When male Sprague Dawley rats weighing ca 160 g were fed theLieber-DeCarli alcohol diet for 3 weeks, their growth rate was 3.8± 0.6 g/day. When the diet was supplemented with calcium phosphate (2.92 g/l), manangese carbonate (20.4 mg/l), ferric citrate (35 mg/l), zinc carbonate (9.3 mg/l), copper carbonate (1.75 mg/l), choline bitartrate (353 mg/l) and pyridoxine hydrochloride (1.2 mg/l), growth increased significantly (4.8±0.8 g/day). The daily weight gain was even greater when rats were fed the Lieber-DeCarli diet having instead of 36%, only 26% calories as alcohol (6.9±1.4 g/day). The amount of diet consumed per day also increased ca 50% as compared to the rats fed the 36% alcohol diet. Thus, the ingestion of more calories and minerals than that by rats fed the Lieber-DeCarli alcohol diet promoted a higher growth rate. Hence, supplementation of the 26% alcohol diet did not exhibit any marked effect on growth. Regardless of feeding the Lieber-DeCarli alcohol diet or its modifications, rats consumed similar amounts of alcohol (22–24 calories) per day. Our observations show that new investigations can now be carried out to examine the effect of chronic alcohol administration under conditions of improved growth in young rats.
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