Liddle syndrome:a case report and review of literature in China

Abstract

Objectives To analysis the features and the early diagnostic signs of Liddle syndrome in China.Methods We retrospectively analyzed the clinical date of 58 Liddle syndrome patients including 1 case in our hospital and other cases reported by 23 literatures in China.Results There were 37 males and 21 femals with the ratio of 1.8:1.The age was from 14 ～ 71 years old averaged( 31.4 ± 15.2) years.The rates for the initial symptoms of Liddle syndrome:hypertension were 39.7％ ( 23/58 ),fatigue and hypokalemia were 8.6％ ( 5/58 ),hypertension and Hypokalemia were 12.1％ (7/58),asymptomatic cases were 39.7％ (23/58).Onset ages were from 10 to 59 years old averaged (22.3 ± 10.4 ) years.The time from onset to diagnosis were from 0 to 30 years averaged ( 8.2 ± 9.6) years.Mean blood pressure of these patients was 130 ～290/70 ～ 240 mmHg,averaged (systolic pressure 195.96 ±39.66,diastolic pressure 123.67 ± 29.1 mmHg).The rates for Liddle syndrome complicated by stroke were 20.7％ (12/58).10.3％ (6/58)patients can maintain normal blood pressure and normokalemia only by given a low - sodium diet or supplying potassium treatment.55.2％ ( 32/58 ) patients need a low - sodium diet 、triamterene and supplying potassium treatment.13.8％ (8/58)patients were given a low -sodium diet、amiloride and supplying potassium treatment.and 15.5％ (9/58)patients should be given other antihypertensive agens to maintain normal blood pressure.Conclusions Liddle syndrome is a disease that can be well treated.So early detection、early diagnosis and treatment can prevent serious complications. Key words: Hyperaldosteronism