LiCO 4/Et 3N: Highly efficient and active catalyst for selective Michael addition of active methylene compounds under solvent-free condition

Abstract

A simple catalyst LiClO 4/Et 3N has been developed and demonstrated to efficiently catalyze Michael addition reactions of active methylene compounds to conjugated ketones, nitriles, esters and nitroalkenes with remarkably high yields and in short reaction time. The Michael addition to nitroalkenes and α,β-unsaturated ketones proceeds quantitatively in the usual way, giving the monoaddition product.