Abstract
BackgroundAn association between lichen simplex chronicus (LSC) and sexual dysfunction was explored. However, no data are available from investigations into the relationship between erectile dysfunction (ED) and LSC.ObjectivesThis retrospective population-based cohort study aimed to clarify the risk of ED associated with LSC.MethodsBy using the Taiwan National Health Insurance Research dataset, we identified 5611 male patients who had been newly diagnosed with LSC from 2000 to 2004. The date of diagnosis was identified as the index date. LSC patients with incomplete demographic information or with a history of ED before the index date were excluded. In total, 22444 age-matched patients without LSC were randomly selected as the non-LSC group based on a 1:4 ratio. Subsequence occurrence of ED was measured until 2011. The association between LSC and the risk of developing ED was estimated using Cox proportional hazard regression model.ResultsAfter adjusting for age and comorbidities, patients with LSC had a 1.74-fold greater risk of developing ED compared with those without LSC (95% confidence interval=1.44–2.10). LSC patients with comorbidities including diabetes, hyperlipidemia, hypertension, cardiovascular disease, peripheral arterial disease, chronic obstructive pulmonary disease, chronic kidney disease, depression, and anxiety were at a higher risk of ED compared with the non-LSC patients without comorbidities.ConclusionsLSC confers a greater risk in the development of ED. Physicians should be aware of the potential of ED occurrence in LSC patients.
Highlights
Lichen simplex chronicus (LSC), known as neurodermatitis, is a common chronic pruritic dermatitis characterized by lichenification of the skin caused by chronic itching and scratching
LSC patients with comorbidities including diabetes, hyperlipidemia, hypertension, cardiovascular disease, peripheral arterial disease, chronic obstructive pulmonary disease, chronic kidney disease, depression, and anxiety were at a higher risk of erectile dysfunction (ED) compared with the non-LSC patients without comorbidities
Physicians should be aware of the potential of ED occurrence in LSC patients
Summary
Lichen simplex chronicus (LSC), known as neurodermatitis, is a common chronic pruritic dermatitis characterized by lichenification of the skin caused by chronic itching and scratching. Various factors incite the development of LSC, and not all are completely understood. Psychogenic factors such as depression, anxiety, obsessive compulsive disorder, dissociative experiences, and sleep disturbances may play a crucial role, contributing to both its development and persistence [3,4,5,6]. LSC dampens the patient’s quality of life (QOL) [7]. An association between lichen simplex chronicus (LSC) and sexual dysfunction was explored. No data are available from investigations into the relationship between erectile dysfunction (ED) and LSC. Academic Editor: Shang-Jyh Hwang, Kaohsiung Medical University HospitalKaohsiung Medical University HospitalKaohsiung Medical University Hospital, TAIWAN
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