Lichen sclerosus in men: clinical efficacy of hydrobiont collagenase isoenzymes electrophoresis in the rehabilitation phase

Abstract

In view of the ineffectiveness of the currently known methods of treatment of men with genital lichen sclerosus (GLS), as well as the lack of substantiated ways of managing patients at the rehabilitation stage, there is a need to search for new approaches to solve this problem. The aim of the work was to study the possibility of applying electrophoresis of an enzyme preparation from hydrobiont collagenases at the stage of rehabilitation of men with GLS. Group 1 consisted of 13 patients aged 36,62±16,04 (main group) who received staged treatment: topical corticosteroids at the first stage and then electrophoresis of the gel consisting of hydrobiont collagenase isoenzymes spectrum at the rehabilitation stage. Group 2 patients (n=14) were 41,93±9,34 years old and received topical corticosteroids therapy at the first stage, and then emollients at the rehabilitation stage. Clinical efficacy of the therapy was evaluated according to scleroatrophic lichen indices: LS-S and LS-A, as well as DLQI after 6 and 16 weeks from the treatment start date. During staged treatment, a more pronounced and long-lasting effect was observed in the group of patients with electrophoresis of the enzyme complex during the rehabilitation stage compared to the group with emollients.