Abstract
Lichen planus is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp, and nails. Lichen planus lesions are described using the six P's (planar (flat-topped), purple, polygonal, pruritic, papules, plaques). This review highlights the Pathophysiology and management of oral and cutaneous lichen planus.
Highlights
Lichen Planus (LP) is a chronic inflammatory and immune mediated disease that affects the skin, nails, hair, and mucous membranes. It was first described by Wilson in 1869 and is thought to affect 0.5–1% of the world’s population Cutaneous Lichen Planus (CLP) most commonly involves the flexor surfaces of the extremities and presents as small itchy violaceous papules in middle-aged adults
The malignant transformation rate of oral lichen planus remains unclear, but estimates range from 0.5% to 3% [3] (Figures 1-3)
High-potency corticosteroids applied to the oral mucosa do not appear to cause significant adrenal suppression, even with relatively long-term use
Summary
Lichen Planus (LP) is a chronic inflammatory and immune mediated disease that affects the skin, nails, hair, and mucous membranes. It was first described by Wilson in 1869 and is thought to affect 0.5–1% of the world’s population Cutaneous Lichen Planus (CLP) most commonly involves the flexor surfaces of the extremities and presents as small itchy violaceous papules in middle-aged adults. Extremities (face, dorsal hands, arms, and nape of neck) This is more common in Middle Eastern countries in spring and summer, where sunlight appears to have a precipitating effect. Lichen Planopilaris is the specific name given to lichen planus on the scalp that causes permanent scarring alopecia with inflammation around affected hair follicles It mostly affects middle-aged adults as distinct patches of hair loss. Hypertrophic lesions are treated with intralesional triamcinolone acetonide (Kenalog), 5 to 10 mg per mL injection (0.5 to 1 mL per 2 cm lesion) Table 1
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