Library synthesis on resin beads

Abstract

Abstract The synthesis of combinatorial libraries usually employs solid phase chemistry. The recent renaissance and growth of interest in solid supported chemistry stems from the opportunity to use filtration as a separation technique to purify both intermediates and final compounds. The ability to synthesize compounds on a resin bead for example, to force the reaction to completion by the addition of excess reagents and monomers, and then being able to remove all the unwanted materials by a simple filtration and wash is at the heart of many library syntheses (Fig. 2.1).This is not to say however, that solution methods are no longer suitable for combinatorial libraries. With appropriate chemistry, either that which is high yielding or that generates products which allow simple liquid-liquid extraction, solution phase library synthesis is highly feasible (see Chapter 4) and indeed has been chosen as a preferred strategy by many academic and industrial groups.