Abstract
Strong evidence exists that amphetamine exerts its peripheral sympathomimetic action mainly by displacing norepinephrine from postganglionic sympathetic nerve endings (1,2). Little is known, however, about the fate of amphetamine and its metabolites within the sympathetic nerve endings. The purpose of the present study was to investigate whether amphetamine and/or its metabolites are stored in postganglionic sympathetic nerves and whether they are liberated by sympathetic nerve stimulation. The present experiments show that at least one metabolite of amphetamine, i.e. p-hydroxynorephedrine is stored in the postganglionic sympathetic nerves of the cat's spleen and liberated by sympathetic nerve stimulation.
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