LHP1 Could Act as an Activator and a Repressor of Transcription in Plants.

Jing Feng,Jiang Lu

doi:10.3389/fpls.2017.02041

Abstract

Polycomb group (PcG) proteins within the polycomb repressive complex 1 (PRC1) and PRC2 are significant epigenetic regulatory factors involved in important cellular and developmental processes in eukaryotes. In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, has been proposed as a plant specific subunit of PRC1 that could bind the trimethylated lysine 27 of histone H3 (H3K27me3), which is established by PRC2 and is required for a functional plant PcG system. LHP1 not only interacts with PRC1 to catalyze monoubiquitination at lysine 119 of histone H2A but also functions with PRC2 to establish H3K27me3. This review is about the interaction of LHP1 with PRC1 and PRC2, in which LHP1 may act as a bridge between the two. Meantime, this review highlights that LHP1 could act as an activator and a repressor of transcription.

Highlights

Reviewed by: Yuhai Cui, Agriculture and Agri-Food Canada (AAFC), Canada Sibum Sung, University of Texas at Austin, United States Keijo Viiri, University of Tampere, Finland
We summarize the recent findings of the role of Polycomb group (PcG) protein, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), during various developmental programs in plants and highlight that LHP1 could act as an activator and a repressor of transcription
LHP1 interacts with several proteins in several pathways to perform its distinct functions

Summary

Introduction

Reviewed by: Yuhai Cui, Agriculture and Agri-Food Canada (AAFC), Canada Sibum Sung, University of Texas at Austin, United States Keijo Viiri, University of Tampere, Finland. PcG proteins form multiprotein Polycomb Repressive Complexes PRC1 and PRC2, which both have functions in the epigenetic repression of gene expression via histone modifications (Bemer and Grossniklaus, 2012; Molitor and Shen, 2013; Grossniklaus and Paro, 2014; Mozgova and Hennig, 2015; Xiao and Wagner, 2015). We summarize the recent findings of the role of PcG protein, LHP1, during various developmental programs in plants and highlight that LHP1 could act as an activator and a repressor of transcription.

Results

Conclusion