LG-48PAEDIATRIC LOW GRADE GLIOMAS - IMPACT OF GROSS TOTAL RESECTION IN A SINGLE CENTRE COHORT

Abstract

LG-48. PAEDIATRIC LOW GRADE GLIOMAS IMPACT OF GROSS TOTAL RESECTION IN A SINGLE CENTRE COHORT Noelle Cullinan1, John Caird2, Michael Capra1, Jane Pears1, Cormac Owens1, andDarachCrimmins2; DepartmentofHaematology/Oncology,Our Lady’s Children’s Hospital, Dublin, Ireland; Department of Paediatric Neurosurgery, Children’s University Hospital, Temple Street, and Beaumont Hospital, Dublin, Ireland AIMS: Completely excised paediatric low grade gliomas (LGGs) are associated with excellent survival rates. Complete resection is not always achievable. We reviewed the Irish neurosurgical experience of paediatric LGGs over a 10-year period. METHODS: We performed a retrospective review of all paediatric patients with LGG diagnosed in the Republic of Ireland between 2005-2014. RESULTS: 112 children were diagnosed over a 10-year period (52 male (46%), 60 female (53%), Age range 0.23–15.87 years, Mean 7.03 years, Median 6.3 years). 111 children had surgical procedures – 14 (13%) had biopsies alone, 16 (14%) had biopsies followed by later resections, while 79 (71%) had upfront craniotomies with resection. We were unable to identify the type of procedure in 2 children. 1 child had a radiological diagnosis of aLGG but no confirmatorybiopsy.79 patientshadupfront craniotomies. In 77/79, all required information was available. 40/77 (52%) had Gross Total Resection (GTR) confirmed by post-operative imaging and 37/77 (48%) had incomplete resections. Of those who had GTR confirmed (excluding patients with Neurofibromatosis Type 1), 3 patients (4%) relapsed or had disease progression in follow-up, with early progression noted, all within 15 months after resection. All others are currently disease free in follow up (96%). CONCLUSION: In those with confirmed GTR on post-operative imaging, recurrence, if it occurred, was early. We propose that scanning intervals can be increased after 2 years and ongoing need for imaging surveillance in those with confirmed GTR should be reviewed. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.48 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.