Lewy body disease with dementia can be well-differentiated from Alzheimer's disease by measurement of cerebral cortical acetylcholinesterase activity by PET

Abstract

IC-P-017 LEWY BODY DISEASE WITH DEMENTIA CAN BE WELL-DIFFERENTIATED FROM ALZHEIMER’S DISEASE BY MEASUREMENT OF CEREBRAL CORTICAL ACETYLCHOLINESTERASE ACTIVITY BY PET Hitoshi Shimada, Hitoshi Shinotoh, Shigeki Hirano, Michie Miyoshi, Koichi Sato, Noriko Tanaka, Tsuneyoshi Ota, Masato Asahina, Akiyo Aotsuka, Kiyoshi Fukushi, Hiroshi Ito, Satoshi Kuwabara, Toshiaki Irie, Tetsuya Suhara, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; Section for Human Neurophysiology, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan; Asahi Hospital for Neurological Diseases and Rehabilitation, Chiba, Japan; Department of Neurology, JR Tokyo General Hospital, Tokyo, Japan; Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, Japan; Department of Psychiatry, Ichihara Hospital, Teikyo University School of Medicine, Chiba, Japan; Department of Neurosurgery, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan; Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; Department of Rehabilitation Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan. Contact e-mail: shim@alpha.ocn.ne.jp