Abstract
AbstractThe present paper reports an efficient, organocatalytic, environmentally friendly and stereoselective [3+3] one‐pot allylic alkylation/oxa‐Michael reaction by involving a wide range of Morita–Baylis–Hillman (MBH) carbonates of isatins and several pharmacologically attractive enolizable C−H activated cyclic carbonyl compounds such as 1,3‐binucleophiles, namely pyrazolones, isoxazolones, 4‐hydroxyxoumarins, 4‐hydroxy‐6‐methyl‐α‐pyrone, lawsone and dimedone in a biomass‐derived 2‐MeTHF as green solvent catalyzed by DABCO as a solid Lewis‐base catalyst. This protocol delivers a unique class of medicinally promising spirooxindole‐fused‐dihydropyran scaffolds.
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