Abstract
The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a−b−) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72–131.63).
Highlights
The AB0 and Lewis blood group systems have both been linked to ischaemic heart disease (IHD)[1,2,3,4]
Severe periodontitis was significantly associated with IHD (P = 0.03, odds ratios (OR): 4.15; CI 95: 1.17–15.67) but not with obesity, stroke or hypertension
We investigated the association of Lewis and AB0 blood groups with PD and sought to confirm previously reported associations between blood group phenotype and hypertension, IHD, stroke, and obesity in a subpopulation of the CAMB-cohort consisting of 702 participants
Summary
The AB0 and Lewis blood group systems have both been linked to ischaemic heart disease (IHD)[1,2,3,4]. Severe periodontitis was significantly associated with IHD (P = 0.03, OR: 4.15; CI 95: 1.17–15.67) but not with obesity, stroke or hypertension (data not shown). No significant associations were observed between AB0 or Lewis blood groups and either of the included definitions of PD.
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