Abstract

Abstract Lewis acid-promoted reaction of ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)propionate (1) with some silylated nucleophiles afforded β,β-difluoroamines in good yields. The formation of iminium ion intermediate from 1 and BF3·OEt2 was confirmed by 19F and 13C NMR spectroscopy.

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