Abstract
Abstract Stereospecific hydroxylation of chiral tertiary alkyl halides using silver salt as Lewis acid catalyst has been developed. A series of α-hydroxy carboxamides were obtained in high yield (up to 90%) and with high enantiospecificity (es; up to 99%). The reaction proceeded in a retentive manner. Control experiments showed that the reaction proceeds via an ionic reaction and that the hydroxide source comes from both water and DMSO.
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