Abstract
Introduction : Levosimendan (L; OrionFarmos Pharmaceuticals) is a novel myofilament calcium sensitizer with phosphodiesterase III inhibiting properties which increases contractile state in vitro by stabilizing calcium-induced changes in troponin C. This investigation examined the effects of L on left ventricular (LV) systolic and diastolic function in conscious dogs with intact or blocked autonomic nervous system (ANS) reflexes.
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