Abstract
Levorphanol-sensitive [ 3H]naloxone binding was measured in brainstems of fetuses and postnatal off-spring of rats injected with morphine or saline or pairfed with morphine-injected animals during the last half of gestation. Brainstem receptor concentrations in saline-injected animals decreased by 25% from gestation day 21 to postnatal day 60, while [ 3H]naloxone binding affinity doubled during the same interval. Chronic morphine exposure decreased receptor concentration at the 21st day of gestation by 28–48%, without changing binding affinity. However, the number and affinity of [ 3H]naloxone binding sites in morphine-injected animals were not different from controls at 60 days postnatally.
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