Abstract
Background: Medroxyprogesterone acetate (MPA) and levonorgestrel intrauterine device (LNG-IUD) are two drugs used to treat abnormal uterine bleeding in women with myoma. We organized this study to compare the effectiveness of these two treatments.
 Methods: This was a retrospective one-year-long cohort study of 95 women with uterine leimyoma. Fifty three women who had received LNG-IUD formed the LNG-IUD group while 42 women who received regular intramuscular injections of 150 mg MPA at every 3 months for one-year period made up the MPA group. Both groups were compared in aspect of demographic, clinical and biochemical characteristics.
 Results: At the end of one year, the LNG-IUD group had significantly smaller fibroid size, lower visual analogus scale score for pelvic pain, for dysmenorrhea and dyspareunia than the MPA group. There were a significant reduction in the number of patients with menorrhagia and a significant increase in serum hemoglobine levels both in LNG-IUD and MPA groups at the end of the one-year long study period.
 Conclusions: LNG-IUD appears as a good choice for the reduction in fibroid size and associated pelvic pain.
Highlights
Uterine leiomyomas, which are known as uterine fibroids, are benign smooth muscle tumors of the uterus
The women in the LNG-IUD and Medroxyprogesterone acetate (MPA) groups were statistically similar in aspect of age, body mass index, gravidity, parity, fibroid size, visual analogue scores (VAS) score for pelvic pain, dysmenorrhea and dyspareunia, serum hemoglobin level and menstrual patterns
When compared with the MPA group, the LNG-IUD group had significantly smaller fibroid size, lower VAS score for pelvic pain, for dysmenorrhea and for dyspareunia (p=0.029, p=0.032, p=0.014 and p=0.040 respectively)
Summary
Uterine leiomyomas, which are known as uterine fibroids, are benign smooth muscle tumors of the uterus They are typically found during the middle and later reproductive years. Fifty three women who had received LNG-IUD formed the LNG-IUD group while 42 women who received regular intramuscular injections of 150 mg MPA at every 3 months for oneyear period made up the MPA group. Both groups were compared in aspect of demographic, clinical and biochemical characteristics. There were a significant reduction in the number of patients with menorrhagia and a significant increase in serum hemoglobine levels both in LNG-IUD and MPA groups at the end of the one-year long study period. Conclusions: LNG-IUD appears as a good choice for the reduction in fibroid size and associated pelvic pain
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