Abstract
Levofloxacin resistance in Haemophilus influenzae has increased significantly in Taiwan, from 2.0% in 2004 to 24.3% in 2010 (p<0.001). Clinical and molecular investigations of 182 levofloxacin-resistant isolates revealed that the increase was mainly the result of the spread of several clones in the elderly population in different regions.
Highlights
Since their first introduction in 1980s, fluoroquinolones have been used extensively [1]
The MIC90 of the 5 fluoroquinolones tested by Etest was >32 μg/mL for the 182 levofloxacin-resistant isolates detected by broth microdilution
Our study indicates that levofloxacin-resistant H. influenzae emerged in Taiwan around 2004 and increased over the 6 years, especially in elderly patients, regional hospitals, and central and southern Taiwan
Summary
Since their first introduction in 1980s, fluoroquinolones have been used extensively [1]. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were performed on levofloxacin-resistant isolates following published protocols [12,13]. Hospitals in the northern (32.1%), central (47.7%), and southern (18.7%) regions of Taiwan provided most of the isolates.
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