Abstract
Urinary tract infections (UTIs) are among the most common reasons for outpatient antibiotic prescriptions. At Denver Community Health Services, which manages >400,000 outpatient visits each year, levofloxacin was substituted as the preferred antibiotic for outpatient UTI therapy in 1999, when the trimethoprim-sulfamethoxazole (TMP-SMX) resistance rate reached 24%. Subsequently, a rise in the levofloxacin resistance rate was observed. The investigators used institutional …
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